Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 3.001


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX3chr5_+_1707362870.591.3e-21Click!
TLX1chr10_+_1028910600.543.0e-18Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_139872014 140.213 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr16_+_222845 109.580 NM_000517
 HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr16_+_226678 102.072 NM_000558
 HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr9_+_139871954 99.060 NM_000954
 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr18_-_74729049 71.449 NM_001025081
NM_001025090
NM_001025092
NM_002385
 MBP



myelin basic protein



chr18_-_74728963 69.730 MBP
myelin basic protein
chr2_-_218843541 60.699 TNS1
tensin 1
chr12_-_56106061 54.937 NM_001144997
 ITGA7
integrin, alpha 7
chr17_-_42992852 52.843 NM_001131019
NM_001242376
NM_002055
 GFAP


glial fibrillary acidic protein


chrX_-_13956530 49.755 GPM6B
glycoprotein M6B
chr2_-_217560247 48.949 NM_000599
 IGFBP5
insulin-like growth factor binding protein 5
chr10_+_106034886 48.478 NM_001191014
NM_001191015
 GSTO2

glutathione S-transferase omega 2

chrX_-_13956445 44.393


chr3_-_58563070 44.265 FAM107A
family with sequence similarity 107, member A
chr8_-_80679897 41.981 NM_001040708
NM_012258
 HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr6_+_150920998 41.750 NM_001029884
 PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr17_-_66951381 38.848 NM_007168
 ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr3_-_195306274 38.128 APOD
apolipoprotein D
chr9_+_124086842 37.971 GSN
gelsolin
chr17_-_15164043 37.395 NM_153322
 PMP22
peripheral myelin protein 22

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 36 entries
enrichment   p-value GO term description
20.50 1.24e-02 GO:0048755 branching morphogenesis of a nerve
8.44 1.77e-02 GO:0010712 regulation of collagen metabolic process
7.45 1.17e-02 GO:0044246 regulation of multicellular organismal metabolic process
6.31 4.82e-02 GO:0007431 salivary gland development
6.31 4.82e-02 GO:0071825 protein-lipid complex subunit organization
6.31 4.82e-02 GO:0071827 plasma lipoprotein particle organization
6.03 7.05e-03 GO:0035272 exocrine system development
2.87 1.66e-02 GO:0001525 angiogenesis
2.47 1.42e-02 GO:0008361 regulation of cell size
2.30 4.15e-02 GO:0001944 vasculature development
2.21 3.51e-02 GO:0032535 regulation of cellular component size
1.70 2.89e-05 GO:0009653 anatomical structure morphogenesis
1.60 1.16e-02 GO:0051239 regulation of multicellular organismal process
1.58 6.25e-03 GO:0009966 regulation of signal transduction
1.56 9.49e-05 GO:0030154 cell differentiation
1.55 9.59e-05 GO:0048869 cellular developmental process
1.52 1.69e-03 GO:0048583 regulation of response to stimulus
1.52 1.29e-02 GO:0023051 regulation of signaling
1.51 2.46e-07 GO:0048856 anatomical structure development
1.51 1.70e-06 GO:0048731 system development

Gene overrepresentation in compartment category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
2.61 1.11e-05 GO:0005578 proteinaceous extracellular matrix
2.58 1.30e-02 GO:0044297 cell body
2.53 2.50e-02 GO:0043025 neuronal cell body
2.50 5.74e-06 GO:0031012 extracellular matrix
2.42 2.24e-05 GO:0009986 cell surface
2.22 1.18e-12 GO:0044421 extracellular region part
2.20 5.11e-09 GO:0005615 extracellular space
2.07 2.93e-12 GO:0031226 intrinsic to plasma membrane
2.05 1.08e-11 GO:0005887 integral to plasma membrane
2.03 7.72e-03 GO:0043005 neuron projection
1.74 1.87e-03 GO:0005626 insoluble fraction
1.72 4.42e-10 GO:0005576 extracellular region
1.72 4.67e-03 GO:0005624 membrane fraction
1.68 4.02e-04 GO:0000267 cell fraction
1.67 1.77e-09 GO:0044459 plasma membrane part
1.60 3.46e-02 GO:0042995 cell projection
1.33 5.75e-05 GO:0005886 plasma membrane
1.31 1.32e-04 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
10.25 2.85e-02 GO:0008191 metalloendopeptidase inhibitor activity
10.25 2.85e-02 GO:0048551 metalloenzyme inhibitor activity
4.56 2.44e-02 GO:0019825 oxygen binding
2.84 4.71e-03 GO:0008083 growth factor activity
2.51 3.32e-02 GO:0005126 cytokine receptor binding
2.20 3.85e-02 GO:0032403 protein complex binding
1.78 7.70e-05 GO:0005102 receptor binding
1.19 1.69e-03 GO:0005515 protein binding